Title: SYNTHETIC CHALLENGES SPANNING GRAMS TO KILOGRAMS FOR EARLY PROCESS DEVELOPMENT OF SMALL MOLECULE AND CONJUGATE DRUG CANDIDATES

Lauren Sirois received her undergraduate degree in Chemistry from Harvard College, where she conducted C-H oxidation research in the laboratory of Prof. M. Christina White. Her Ph.D. dissertation with Prof. Paul Wender at Stanford University focused on the development of new transition metal-catalyzed cycloaddition reactions and their applications. Lauren began her industrial career as a Research Scientist at Lexicon Pharmaceuticals (New Jersey, USA), where she worked as part of the Chemical Development team to support synthesis and manufacturing activities for small molecule active pharmaceutical ingredients, at scales ranging from preclinical to Phase II clinical supply. In 2014, Lauren transitioned to a role as Scientist in Genentech's Small Molecule Process Chemistry department (California, USA). She has contributed to a number of early development programs by leading chemistry teams for drug candidates in the small molecule, antibody-drug conjugate, and therapeutic peptide space. During her graduate studies, Lauren was a recipient of a National Science Foundation Predoctoral Fellowship, and a finalist for the Reaxys PhD Prize. In addition to volunteer work organizing seminars and symposia, she continues to publish in peer-reviewed journals and present her research to external audiences, most recently at the American Chemical Society National Meetings and the Gordon Research Conferences.